Senior Scientist, In Vivo Early Oncology BioScience
AstraZeneca

Senior Scientist, In Vivo Early Oncology BioScience - Waltham, MA

Do you have expertise in, and a passion for redefining cancer, redefining our solutions to cancer, and restoring patients' lives? Would you like to apply your expertise in in vivo pharmacology in a company that follows the science and turns ideas into life changing medicines? AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.

At AZ, we're proud to have an exceptional workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives - and made to feel valued, energized and rewarded for their ideas and creativity. AZ is a place where passionate people can immerse themselves in their work and make significant contributions to scientific excellence and medicines - does this describe a place where you would like to work?

At AstraZeneca Oncology, we are not afraid to do things differently. Our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives. As a motivated in vivo Senior Scientist, you will join a dynamic and collaborative in vivo pharmacology team in our state of the art Biohub facility in Waltham MA. Your primary responsibility of this position is to build in vivo animal models/assays, conduct PK, PD, efficacy, and ex vivo studies to support our growing Oncology R&D portfolio. These efforts will ultimately lead to the identification of drug candidates to support our growing epigenetics portfolio and the generation of compelling preclinical data packages to progress promising drug discovery projects toward clinical development.

What you'll do:

• Use expert in vivo technical skills to support our growing portfolio by:
  • Developing and working with various in vivo models of cancer ranging from subcutaneous xenograft tumor models, orthotopic models, and PDX models.
  • Conducting in vivo pharmacology studies (tolerability, PK/PD and efficacy) and delivering comprehensive in vivo pharmacology data packages to support both early and late stage drug discovery programs.
  • Performing model development studies to generate relevant in vivo models that support the screening cascade for a pathway of interest
• Demonstrate proficiency and flexibility in working with various computer programs and databases to capture all study data for broad access by project teams and stakeholders.
• Work collaboratively across functional disciplines to develop and implement aggressive work plans and timelines.

• Bring in new technologies and approaches to improve or replace existing disease model platforms that better predict clinical response.
• Lead from the bench by delivering the in vivo data, analyzing, and presenting the data to the project teams.

Education, Qualifications, Skills and Experience:

Essential Requirements:

• BS or MS in pharmacology or related field with a minimum of 5-7 years relevant BioPharma experience preferred.
• Demonstrated expertise in generating and working with various animal models in an industry setting.
• Experience delivering all aspects of in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD studies, collection of blood and plasma via cardiac puncture and/or tail vein microsampling, and delivery of efficacy studies.
• Demonstrated ability to develop and analyze PD response in various tissues including (but not limited to) tumor.
• Ability to harvest and prepare tissues for various endpoints including flow cytometry analysis, western blot analysis, PK analysis, and IHC.
• Ability to work independently, as well as within project teams, and across disciplines.
• Ability to lead from the bench in problem solving and in the development of innovative solutions.
• Excellent communication and presentation skills.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big! Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

Site Description

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

So, what's next?

A place built on courage, curiosity, and collaboration - we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline.

If you are swift to action, confident to lead, willing to collaborate, and passionate about the possibilities, then we are keen to hear from you.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Next steps:

Apply today, or connect with our Talent Acquisition Partner - Kayla Harris: https://www.linkedin.com/in/kayla-harris-8723ab13b/ for a confidential discussion to explore this opportunity further. We are looking forward to hearing from you!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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