The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Client's portfolio to help make medicines safer and more effective. We are looking for a Research Associate Scientist to support these efforts across platforms and modalities. The Research Associate Scientist will contribute ideas and deliver decision-making data to inform project teams on improved efficacy and/or de-risking of potential toxicities.
- Work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated client's assets.
- Design and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidates.
- Conduct cell-basedin vitroassays to characterize toxicities for medicines in discovery & development.
- Develop novelin vitromodel systems to assess safety risks associated client's assets.
- Develop, design, execute, and interpretin vitrocell-based assays to characterize diverse mechanisms of toxicity.
- Maintain cultures of immortalized tumor cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, blood etc.) with primary focus being on primary CD34+ cells and differentiating CD34+ cells to various cell types.
- Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings.
- Contribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics).
- Good documentation practices are required.
- Ph.D. with 0-1 years or MS. with 3+ years or BS with 5+ years of experience in biology, biochemistry, pharmacology, or a related discipline.
- Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells. Experience with culturing and differentiating CD34+ cells is a plus.
- Broad experience with cell-based functional assays. Experience with cell transfection/transduction, imaging, and flow cytometry is a plus.
- Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, western blot
- Experience working in a matrixed team environment at a pharmaceutical company and/or CRO.
- Broad scientific knowledge in hematology, immunology, and pharmacology.
- Self-motivated with strong time management and organizational skills.
Position is full-time, Monday - Friday 8:00am - 5:00pm.Candidates currently living within a commutable distance of Cambridge, MAare encouraged to apply.Excellent full time benefits including comprehensive medical coverage, dental, and vision options.
Eurofins is aM/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays